Publications from CRLB

The challenge of establishing, growing and sustaining a large biobank: a personal perspective.

Clin Biochem. 2014 Mar;47(4-5):239-44

McQueen MJ, Keys JL, Bamford K, Hall K

Measurement of hemoglobin A1c from filter papers for population-based studies.

Clin Chem. 2011 Apr;57(4):577-85

Egier DA, Keys JL, Hall SK, McQueen MJ


Recent Publications Authored/Co-Authored by CRLB Investigators

Clinical Validation of a Genome-Wide DNA Methylation Assay for Molecular Diagnosis of Imprinting Disorders.

J Mol Diagn. 2017 Aug 11. pii: S1525-1578(17)30263-5

HDL Cholesterol, LDL Cholesterol, and Triglycerides as Risk Factors for CKD: A Mendelian Randomization Study.

Am J Kidney Dis. 2017 Jul 26. pii: S0272-6386(17)30791-6

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09438

DNA methylation predicts stroke outcome better: The epigenetic clock is ticking.

Neurology. 2017 Aug 22;89(8):758-759.

Mendelian Genes and Risk of Intracerebral Hemorrhage and Small-Vessel Ischemic Stroke in Sporadic Cases.

Stroke. 2017 Aug;48(8):2263-2265

Gene Expression Profiles for the Identification of Prevalent Atrial Fibrillation.

J Am Heart Assoc. 2017 Jun 30;6(7)

Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.

PLoS Genet. 2017 Jun 14;13(6):e1006812

Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery.

JAMA. 2017 Apr 25;317(16):1642-1651

Polygenic risk score predicts prevalence of cardiovascular disease in patients with familial hypercholesterolemia.

J Clin Lipidol. 2017 May – Jun;11(3):725-732

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Nat Genet. 2017 Jun;49(6):946-952

Validation of the ORIGIN Cardiovascular Biomarker Panel and the Value of Adding Troponin I in Dysglycemic People.

J Clin Endocrinol Metab. 2017 Mar 24. doi: 10.1210/jc.2017-00273

The 9p21.3 locus and cardiovascular risk in familial hypercholesterolemia.

J Clin Lipidol. 2017 Mar – Apr;11(2):406-412

Association between cannabis use and methadone maintenance treatment outcomes: an investigation into sex differences.

Biol Sex Differ. 2017 Mar 30;8:8

The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy.

Addict Sci Clin Pract. 2017 Mar 28;12(1):9

Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome.

Epigenetics Chromatin. 2017 Mar 10;10:10

Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy.

Circ Cardiovasc Genet. 2017 Apr;10(2)

Once versus twice daily aspirin after coronary bypass surgery: a randomized trial.

J Thromb Haemost. 2017 May;15(5):889-896

Molecular phenotype and bleeding risks of an inherited platelet disorder in a family with a RUNX1 frameshift mutation.

Haemophilia. 2017 May;23(3):e204-e213

Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study.

Sci Rep. 2017 Mar 6;7(1):68

Alcohol and Cardiovascular Disease: How Much is Too Much?

Curr Atheroscler Rep. 2017 Mar;19(3):13

Clinical evaluation of a hemochromatosis next-generation sequencing gene panel.

Eur J Haematol. 2017 Mar;98(3):228-234

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.

Lancet Diabetes Endocrinol. 2017 Feb;5(2):97-105

Economic Considerations of Early Rule-In/Rule-Out Algorithms for The Diagnosis of Myocardial Infarction in The Emergency Department Using Cardiac Troponin and Glycemic Biomarkers.

Clin Chem. 2017 Feb;63(2):593-602

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin.

Diabetes Care. 2017 Feb;40(2):280-283

Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population.

Clin Res Cardiol. 2017 Feb;106(2):96-104

Cannabis use and risk of schizophrenia: a Mendelian randomization study.

Mol Psychiatry. 2017 Jan 24

Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.

J Biol Chem. 2017 Jan 27;292(4):1510-1523

Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome.

Clin Chem. 2017 Jan;63(1):403-414.

Relationships of Measured and Genetically Determined Height With the Cardiac Conduction System in Healthy Adults.

Circ Arrhythm Electrophysiol. 2017 Jan;10

The defining DNA methylation signature of Floating-Harbor Syndrome.

Sci Rep. 2016 Dec 9;6:38803.

Impact of a Genetic Risk Score on Myocardial Infarction Risk Across Different Ethnic Populations.

Can J Cardiol. 2016 Dec;32(12):1440-1446

Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol.

BMJ Open. 2016 Nov 22;6(11):e012351

A Risk Assessment Tool Incorporating New Biomarkers for Cardiovascular Events in Acute Coronary Syndromes: The Organization to Assess Strategies in Ischemic Syndromes (OASIS) Risk Score.

Can J Cardiol. 2016 Nov;32(11):1332-1339.

Clinical Validation of Fragile X Syndrome Screening by DNA Methylation Array.

J Mol Diagn. 2016 Nov;18(6):834-841

Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial.

Diabetes Care. 2016 Nov;39(11):1915-1924.

Determinants of Left Atrial Volume in Patients with Atrial Fibrillation.

PLoS One. 2016 Oct 4;11(10):e0164145

Frameshift mutation in the APOA5 gene causing hypertriglyceridemia in a Pakistani family: Management and considerations for cardiovascular risk.

J Clin Lipidol. 2016 Sep-Oct;10(5):1272-7.

Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.

Clin Epigenetics. 2016 Sep 5;8:91

Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy.

Pharmacogenomics. 2016 Aug;17(13):1425-39

A Digital Health Intervention to Lower Cardiovascular Risk: A Randomized Clinical Trial.

JAMA Cardiol. 2016 Aug 1;1(5):601-6

Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study.

Lancet. 2016 Aug 20;388(10046):761-75

Whole Blood Gene Expression Differentiates between Atrial Fibrillation and Sinus Rhythm after Cardioversion.

PLoS One. 2016 Jun 22;11(6):e0157550

A method to estimate the contribution of regional genetic associations to complex traits from summary association statistics.

Sci Rep. 2016 Jun 8;6:27644

Putting the Genome in Context: Gene-Environment Interactions in Type 2 Diabetes.

Curr Diab Rep. 2016 Jul;16(7):57

A Prospective Study to Investigate Predictors of Relapse among Patients with Opioid Use Disorder Treated with Methadone.

Subst Abuse. 2016 Apr 10;10:9-18.

Telomere Length and Risk of Myocardial Infarction in a MultiEthnic Population: The INTERHEART Study.

J Am Coll Cardiol. 2016 Apr 19;67(15):1863-5

Pain and Opioid Addiction: A Systematic Review and Evaluation of Pain Measurement in Patients with Opioid Dependence on Methadone Maintenance Treatment.

Curr Drug Abuse Rev. 2016;9(1):49-60

Roles for miR-375 in Neuroendocrine Differentiation and Tumor Suppression via Notch Pathway Suppression in Merkel Cell Carcinoma.

Am J Pathol. 2016 Apr;186(4):1025-35

Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.

Stroke. 2016 Mar;47(3):652-8

DNA methylation analysis in constitutional disorders: Clinical implications of the epigenome.

Crit Rev Clin Lab Sci. 2016 Jun;53(3):147-65

Usefulness of the Brief Pain Inventory in Patients with Opioid Addiction Receiving Methadone Maintenance Treatment.

Pain Physician. 2016 Jan;19(1):E181-95

Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.

Neurology. 2016 Jan 12;86(2):146-53

PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes.

J Thromb Thrombolysis. 2015 Nov 16

Sex differences in substance use, health, and social functioning among opioid users receiving methadone treatment: a multicenter cohort study.

Biol Sex Differ. 2015;6:21

Dabigatran etexilate and reduction in serum apolipoprotein B.

Heart. 2016 Jan 1;102(1):57-62

Identifying Novel Biomarkers for Cardiovascular Events or Death in People With Dysglycemia.

Circulation. 2015 Dec 15;132(24):2297-304

Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria.

Trials. 2015;16:475

Sex differences in outcomes of methadone maintenance treatment for opioid use disorder: a systematic review and meta-analysis.

CMAJ Open. 2015 Jul-Sep;3(3):E344-51

Assessment of Dietary Sodium and Potassium in Canadians Using 24-Hour Urinary Collection.

Can J Cardiol. 2016 Mar;32(3):319-26

Contribution of BDNF and DRD2 genetic polymorphisms to continued opioid use in patients receiving methadone treatment for opioid use disorder: an observational study.

Addict Sci Clin Pract. 2015;10:19

Impact of Chronic Pain on Treatment Prognosis for Patients with Opioid Use Disorder: A Systematic Review and Meta-analysis.

Subst Abuse. 2015;9:59-80

Association of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) With Cardiovascular Risk in Primary Prevention.

Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2254-9

The Relationship Between Trimethylamine-N-Oxide and Prevalent Cardiovascular Disease in a Multiethnic Population Living in Canada.

Can J Cardiol. 2015 Sep;31(9):1189-94

Electronic health record usage behaviors in primary care medical practices: A survey of family physicians in Canada.

Int J Med Inform. 2015 Oct;84(10):857-67

Genome-wide studies to identify risk factors for kidney disease with a focus on patients with diabetes.

Nephrol Dial Transplant. 2015 Aug;30 Suppl 4:iv26-34

Overlap Chronic Placental Inflammation Is Associated with a Unique Gene Expression Pattern.

PLoS One. 2015;10(7):e0133738

Use of genetic data to guide therapy in arterial disease.

J Thromb Haemost. 2015 Jun;13 Suppl 1:S281-9

Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia.

Eur J Haematol. 2015 Jun 8;

Effect of Bile Acid Sequestrants on the Risk of Cardiovascular Events: A Mendelian Randomization Analysis.

Circ Cardiovasc Genet. 2015 Aug;8(4):618-27

The impact of chronic pain on opioid addiction treatment: a systematic review protocol.

Syst Rev. 2015;4:49

Improving performance in medical practices through the extended use of electronic medical record systems: a survey of Canadian family physicians.

BMC Med Inform Decis Mak. 2015;15:27

Contribution of large region joint associations to complex traits genetics.

PLoS Genet. 2015 Apr;11(4):e1005103

Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease.

Eur Heart J. 2015 Jun 14;36(23):1454-62

Effects of home telemonitoring interventions on patients with chronic heart failure: an overview of systematic reviews.

J Med Internet Res. 2015;17(3):e63

Examining the clinical use of hemochromatosis genetic testing.

Can J Gastroenterol Hepatol. 2015 Jan-Feb;29(1):41-5

Testosterone suppression in opioid users: a systematic review and meta-analysis.

Drug Alcohol Depend. 2015 Apr 1;149:1-9

Genetic studies of body mass index yield new insights for obesity biology.

Nature. 2015 Feb 12;518(7538):197-206

New genetic loci link adipose and insulin biology to body fat distribution.

Nature. 2015 Feb 12;518(7538):187-96

Adoption, use, and impact of e-booking in private medical practices: mixed-methods evaluation of a two-year showcase project in Canada.

JMIR Med Inform. 2014;2(2):e24

Active metabolite concentration of clopidogrel in patients taking different doses of aspirin: results of the interaction trial.

J Thromb Haemost. 2015 Mar;13(3):347-52

Multiple daily doses of acetyl-salicylic acid (ASA) overcome reduced platelet response to once-daily ASA after coronary artery bypass graft surgery: a pilot randomized controlled trial.

J Thromb Haemost. 2015 Mar;13(3):448-56

Recommendations from the international stroke genetics consortium, part 2: biological sample collection and storage.

Stroke. 2015 Jan;46(1):285-90

Variability of ethics education in laboratory medicine training programs: results of an international survey.

Clin Chim Acta. 2015 Mar 10;442:115-8

Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation.

Neuropsychiatr Dis Treat. 2014;10:2239-47

Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis.

Circ Cardiovasc Genet. 2015 Feb;8(1):82-90

A robust method for iodine status determination in epidemiological studies by capillary electrophoresis.

Anal Chem. 2014 Oct 21;86(20):10010-5

The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol.

Syst Rev. 2014;3:105

A gene variant in CERS2 is associated with rate of increase in albuminuria in patients with diabetes from ONTARGET and TRANSCEND.

PLoS One. 2014;9(9):e106631

The preventive potential of common, easily measured risk factors for cardiovascular disease.

Clin Chem. 2014 Nov;60(11):1450-1

Genetic influence on methadone treatment outcomes in patients undergoing methadone maintenance treatment for opioid addiction: a pilot study.

Neuropsychiatr Dis Treat. 2014;10:1503-8

Methadone induces testosterone suppression in patients with opioid addiction.

Sci Rep. 2014;4:6189

Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?

Diabetologia. 2014 Nov;57(11):2270-81

Urinary sodium and potassium excretion, mortality, and cardiovascular events.

N Engl J Med. 2014 Aug 14;371(7):612-23

Association of urinary sodium and potassium excretion with blood pressure.

N Engl J Med. 2014 Aug 14;371(7):601-11

Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.

Neurology. 2014 Aug 19;83(8):678-85

The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.

Drug Metabol Drug Interact. 2014;29(3):143-51

Barriers to organizational adoption of EMR systems in family physician practices: a mixed-methods study in Canada.

Int J Med Inform. 2014 Aug;83(8):548-58

Research capacity. Enabling the genomic revolution in Africa.

Science. 2014 Jun 20;344(6190):1346-8