Publications – CRLB-GMEL

Highest Impact

Landmark Publications

Selected high-impact publications from CRLB-GMEL investigators representing major contributions to cardiovascular, genetic, and population health research.

Nature 2022 · Stroke Genetics

Stroke genetics informs drug discovery and risk prediction across ancestries

Nature. 2022;611(7934):115–123 · Mishra A, Malik R … Chong M … Paré G … Debette S · PMID 36180795

Lancet 2020 · PURE Biomarkers

Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis

Lancet. 2020;396(10256):968–976 · Narula S, Yusuf S, Chong M … Paré G · PMID 33010842

Circulation 2019 · Proteomics

Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome

Circulation. 2019;140(10):819–830 · Chong M, Sjaarda J … Paré G · PMID 31208196

Nat Genet 2018 · Stroke GWAS

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Nat Genet. 2018;50(4):524–537 · Malik R, Chauhan G … Chong M … Paré G … Dichgans M · PMID 29531354

JAMA 2017 · VISION

Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery

JAMA. 2017;317(16):1642–1651 · Devereaux PJ … Kavsak P, McQueen MJ … VISION Study Investigators · PMID 28444280

Lancet Diabetes Endocrinol 2017

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Lancet Diabetes Endocrinol. 2017;5(2):97–105 · Schmidt AF … Chong M, Paré G … international consortium · PMID 27908689

Lancet 2016 · INTERSTROKE

Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study

Lancet. 2016;388(10046):761–775 · O’Donnell MJ … McQueen MJ … Paré G, Yusuf S · PMID 27431356

Circulation 2015 · ORIGIN

Identifying Novel Biomarkers for Cardiovascular Events or Death in People With Dysglycemia

Circulation. 2015;132(24):2297–2304 · Gerstein HC, Paré G, McQueen MJ … ORIGIN investigators · PMID 26518765

NEJM 2014 · PURE

Urinary sodium and potassium excretion, mortality, and cardiovascular events

N Engl J Med. 2014;371(7):612–623 · O’Donnell M, Mente A, Rangarajan S … McQueen MJ … PURE investigators · PMID 25119607

Clin Biochem 2014 · Biobanking

The challenge of establishing, growing and sustaining a large biobank: a personal perspective

Clin Biochem. 2014;47(4-5):239–244 · McQueen MJ, Keys JL, Bamford K, Hall K · PMID 24316099

From the Laboratory

CRLB Publications

Publications from CRLB laboratory operations, methods development, biobank science, and analytical research.

1
Important quality parameters for macrocomplex investigation for cardiac troponin.
Kavsak PA, Choi WS, Malinowski P, Demian WL, Tandon V, Ainsworth C
Clin Biochem. 2025 Jan;135:110866
2
Analytical assessment of Ortho Clinical Diagnostics high-sensitivity cardiac troponin I assay.
Kavsak PA, Edge T, Roy C, Malinowski P, Bamford K, Clark L, Lamers S, Hill S, Worster A
Clin Chem Lab Med. 2021 Mar 26;59(4):749–755
3
Macrocomplexes and high-sensitivity cardiac troponin assays in samples stored for over 15 years.
Kavsak PA, Clark L, Caruso N, Bamford K, Lamers S, Hill S, Worster A
Clin Chim Acta. 2020 Jun;505:6–8
4
Sample matrix and high-sensitivity cardiac troponin I assays.
Kavsak PA, Roy C, Malinowski P, Clark L, Lamers S, Bamford K, Hill S, Worster A, Jaffe AS
Clin Chem Lab Med. 2019 Apr 24;57(5):745–751
5
Differences in total PSA results within and between manufacturers.
Kittanakom S, Clark L, Roy C, Malinowski P, Bamford K, Lamers S, Kavsak PA
Clin Biochem. 2018 Sep;60:91–92
6
Macrocomplexes and discordant high-sensitivity cardiac troponin concentrations.
Kavsak PA, Roy C, Malinowski P, Mark CT, Scott T, Clark L, Lamers S, Ainsworth C
Ann Clin Biochem. 2018 Jul;55(4):500–504
7
Assessing matrix, interferences and comparability between the Abbott Diagnostics and the Beckman Coulter high-sensitivity cardiac troponin I assays.
Kavsak PA, Malinowski P, Roy C, Clark L, Lamers S
Clin Chem Lab Med. 2018 Jun 27;56(7):1176–1181
8
Validation of the ORIGIN Cardiovascular Biomarker Panel and the Value of Adding Troponin I in Dysglycemic People.
Gerstein HC, Paré G, McQueen MJ, et al.
J Clin Endocrinol Metab. 2017 Jul 1;102(7):2251–2257
9
A robust method for iodine status determination in epidemiological studies by capillary electrophoresis.
de Macedo AN, Teo K, Mente A, McQueen MJ, et al.
Anal Chem. 2014 Oct 21;86(20):10010–10015
10
The preventive potential of common, easily measured risk factors for cardiovascular disease.
McQueen MJ, Yusuf S
Clin Chem. 2014 Nov;60(11):1450–1451
11
The challenge of establishing, growing and sustaining a large biobank: a personal perspective.
McQueen MJ, Keys JL, Bamford K, Hall K
Clin Biochem. 2014 Mar;47(4-5):239–244
12
Measurement of hemoglobin A1c from filter papers for population-based studies.
Egier DA, Keys JL, Hall SK, McQueen MJ
Clin Chem. 2011 Apr;57(4):577–585

Active Investigator · Lab Director

Guillaume Paré

Director, CRLB-GMEL · Senior Scientist, PHRI · Professor, Pathology & Molecular Medicine, McMaster. Over 250 publications cited 35,000+ times in cardiovascular genetics, proteomics, and biomarker discovery. Showing 10 most recent.

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Active Investigator · Deputy Director

Matthew J. McQueen

Co-founder of the CRLB (1987) and Deputy Director of CRLB-GMEL. Over 250 publications in clinical biochemistry, cardiovascular risk, and biobanking. Showing 10 most recent.

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Active Investigator · Assistant Director

Michael Chong

Assistant Director, CRLB-GMEL · PHRI Investigator · Assistant Professor, McMaster. Over 60 publications in stroke and cardiovascular genetics, mitochondrial genomics, and bioinformatics. Showing 10 most recent.

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