Publications from CRLB
The challenge of establishing, growing and sustaining a large biobank: a personal perspective.
Clin Biochem. 2014 Mar;47(4-5):239-44
McQueen MJ, Keys JL, Bamford K, Hall K
Measurement of hemoglobin A1c from filter papers for population-based studies.
Clin Chem. 2011 Apr;57(4):577-85
Egier DA, Keys JL, Hall SK, McQueen MJ
Recent Publications Authored/Co-Authored by CRLB Investigators
Clinical Validation of a Genome-Wide DNA Methylation Assay for Molecular Diagnosis of Imprinting Disorders.
J Mol Diagn. 2017 Aug 11. pii: S1525-1578(17)30263-5
HDL Cholesterol, LDL Cholesterol, and Triglycerides as Risk Factors for CKD: A Mendelian Randomization Study.
Am J Kidney Dis. 2017 Jul 26. pii: S0272-6386(17)30791-6
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09438
DNA methylation predicts stroke outcome better: The epigenetic clock is ticking.
Neurology. 2017 Aug 22;89(8):758-759.
Mendelian Genes and Risk of Intracerebral Hemorrhage and Small-Vessel Ischemic Stroke in Sporadic Cases.
Stroke. 2017 Aug;48(8):2263-2265
Gene Expression Profiles for the Identification of Prevalent Atrial Fibrillation.
J Am Heart Assoc. 2017 Jun 30;6(7)
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.
PLoS Genet. 2017 Jun 14;13(6):e1006812
Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery.
JAMA. 2017 Apr 25;317(16):1642-1651
Polygenic risk score predicts prevalence of cardiovascular disease in patients with familial hypercholesterolemia.
J Clin Lipidol. 2017 May – Jun;11(3):725-732
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
Nat Genet. 2017 Jun;49(6):946-952
Validation of the ORIGIN Cardiovascular Biomarker Panel and the Value of Adding Troponin I in Dysglycemic People.
J Clin Endocrinol Metab. 2017 Mar 24. doi: 10.1210/jc.2017-00273
The 9p21.3 locus and cardiovascular risk in familial hypercholesterolemia.
J Clin Lipidol. 2017 Mar – Apr;11(2):406-412
Association between cannabis use and methadone maintenance treatment outcomes: an investigation into sex differences.
Biol Sex Differ. 2017 Mar 30;8:8
The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy.
Addict Sci Clin Pract. 2017 Mar 28;12(1):9
Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome.
Epigenetics Chromatin. 2017 Mar 10;10:10
Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy.
Circ Cardiovasc Genet. 2017 Apr;10(2)
Once versus twice daily aspirin after coronary bypass surgery: a randomized trial.
J Thromb Haemost. 2017 May;15(5):889-896
Molecular phenotype and bleeding risks of an inherited platelet disorder in a family with a RUNX1 frameshift mutation.
Haemophilia. 2017 May;23(3):e204-e213
Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study.
Sci Rep. 2017 Mar 6;7(1):68
Alcohol and Cardiovascular Disease: How Much is Too Much?
Curr Atheroscler Rep. 2017 Mar;19(3):13
Clinical evaluation of a hemochromatosis next-generation sequencing gene panel.
Eur J Haematol. 2017 Mar;98(3):228-234
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.
Lancet Diabetes Endocrinol. 2017 Feb;5(2):97-105
Economic Considerations of Early Rule-In/Rule-Out Algorithms for The Diagnosis of Myocardial Infarction in The Emergency Department Using Cardiac Troponin and Glycemic Biomarkers.
Clin Chem. 2017 Feb;63(2):593-602
Growth Differentiation Factor 15 as a Novel Biomarker for Metformin.
Diabetes Care. 2017 Feb;40(2):280-283
Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population.
Clin Res Cardiol. 2017 Feb;106(2):96-104
Cannabis use and risk of schizophrenia: a Mendelian randomization study.
Mol Psychiatry. 2017 Jan 24
Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.
J Biol Chem. 2017 Jan 27;292(4):1510-1523
Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome.
Clin Chem. 2017 Jan;63(1):403-414.
Relationships of Measured and Genetically Determined Height With the Cardiac Conduction System in Healthy Adults.
Circ Arrhythm Electrophysiol. 2017 Jan;10
The defining DNA methylation signature of Floating-Harbor Syndrome.
Sci Rep. 2016 Dec 9;6:38803.
Impact of a Genetic Risk Score on Myocardial Infarction Risk Across Different Ethnic Populations.
Can J Cardiol. 2016 Dec;32(12):1440-1446
Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol.
BMJ Open. 2016 Nov 22;6(11):e012351
A Risk Assessment Tool Incorporating New Biomarkers for Cardiovascular Events in Acute Coronary Syndromes: The Organization to Assess Strategies in Ischemic Syndromes (OASIS) Risk Score.
Can J Cardiol. 2016 Nov;32(11):1332-1339.
Clinical Validation of Fragile X Syndrome Screening by DNA Methylation Array.
J Mol Diagn. 2016 Nov;18(6):834-841
Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial.
Diabetes Care. 2016 Nov;39(11):1915-1924.
Determinants of Left Atrial Volume in Patients with Atrial Fibrillation.
PLoS One. 2016 Oct 4;11(10):e0164145
Frameshift mutation in the APOA5 gene causing hypertriglyceridemia in a Pakistani family: Management and considerations for cardiovascular risk.
J Clin Lipidol. 2016 Sep-Oct;10(5):1272-7.
Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.
Clin Epigenetics. 2016 Sep 5;8:91
Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy.
Pharmacogenomics. 2016 Aug;17(13):1425-39
A Digital Health Intervention to Lower Cardiovascular Risk: A Randomized Clinical Trial.
JAMA Cardiol. 2016 Aug 1;1(5):601-6
Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study.
Lancet. 2016 Aug 20;388(10046):761-75
Whole Blood Gene Expression Differentiates between Atrial Fibrillation and Sinus Rhythm after Cardioversion.
PLoS One. 2016 Jun 22;11(6):e0157550
A method to estimate the contribution of regional genetic associations to complex traits from summary association statistics.
Sci Rep. 2016 Jun 8;6:27644
Putting the Genome in Context: Gene-Environment Interactions in Type 2 Diabetes.
Curr Diab Rep. 2016 Jul;16(7):57
A Prospective Study to Investigate Predictors of Relapse among Patients with Opioid Use Disorder Treated with Methadone.
Subst Abuse. 2016 Apr 10;10:9-18.
Telomere Length and Risk of Myocardial Infarction in a MultiEthnic Population: The INTERHEART Study.
J Am Coll Cardiol. 2016 Apr 19;67(15):1863-5
Pain and Opioid Addiction: A Systematic Review and Evaluation of Pain Measurement in Patients with Opioid Dependence on Methadone Maintenance Treatment.
Curr Drug Abuse Rev. 2016;9(1):49-60
Roles for miR-375 in Neuroendocrine Differentiation and Tumor Suppression via Notch Pathway Suppression in Merkel Cell Carcinoma.
Am J Pathol. 2016 Apr;186(4):1025-35
Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.
Stroke. 2016 Mar;47(3):652-8
DNA methylation analysis in constitutional disorders: Clinical implications of the epigenome.
Crit Rev Clin Lab Sci. 2016 Jun;53(3):147-65
Usefulness of the Brief Pain Inventory in Patients with Opioid Addiction Receiving Methadone Maintenance Treatment.
Pain Physician. 2016 Jan;19(1):E181-95
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.
Neurology. 2016 Jan 12;86(2):146-53
PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes.
J Thromb Thrombolysis. 2015 Nov 16
Sex differences in substance use, health, and social functioning among opioid users receiving methadone treatment: a multicenter cohort study.
Biol Sex Differ. 2015;6:21
Dabigatran etexilate and reduction in serum apolipoprotein B.
Heart. 2016 Jan 1;102(1):57-62
Identifying Novel Biomarkers for Cardiovascular Events or Death in People With Dysglycemia.
Circulation. 2015 Dec 15;132(24):2297-304
Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria.
Sex differences in outcomes of methadone maintenance treatment for opioid use disorder: a systematic review and meta-analysis.
CMAJ Open. 2015 Jul-Sep;3(3):E344-51
Assessment of Dietary Sodium and Potassium in Canadians Using 24-Hour Urinary Collection.
Can J Cardiol. 2016 Mar;32(3):319-26
Contribution of BDNF and DRD2 genetic polymorphisms to continued opioid use in patients receiving methadone treatment for opioid use disorder: an observational study.
Addict Sci Clin Pract. 2015;10:19
Impact of Chronic Pain on Treatment Prognosis for Patients with Opioid Use Disorder: A Systematic Review and Meta-analysis.
Subst Abuse. 2015;9:59-80
Association of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) With Cardiovascular Risk in Primary Prevention.
Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2254-9
The Relationship Between Trimethylamine-N-Oxide and Prevalent Cardiovascular Disease in a Multiethnic Population Living in Canada.
Can J Cardiol. 2015 Sep;31(9):1189-94
Electronic health record usage behaviors in primary care medical practices: A survey of family physicians in Canada.
Int J Med Inform. 2015 Oct;84(10):857-67
Genome-wide studies to identify risk factors for kidney disease with a focus on patients with diabetes.
Nephrol Dial Transplant. 2015 Aug;30 Suppl 4:iv26-34
Overlap Chronic Placental Inflammation Is Associated with a Unique Gene Expression Pattern.
PLoS One. 2015;10(7):e0133738
Use of genetic data to guide therapy in arterial disease.
J Thromb Haemost. 2015 Jun;13 Suppl 1:S281-9
Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia.
Eur J Haematol. 2015 Jun 8;
Effect of Bile Acid Sequestrants on the Risk of Cardiovascular Events: A Mendelian Randomization Analysis.
Circ Cardiovasc Genet. 2015 Aug;8(4):618-27
The impact of chronic pain on opioid addiction treatment: a systematic review protocol.
Syst Rev. 2015;4:49
Improving performance in medical practices through the extended use of electronic medical record systems: a survey of Canadian family physicians.
BMC Med Inform Decis Mak. 2015;15:27
Contribution of large region joint associations to complex traits genetics.
PLoS Genet. 2015 Apr;11(4):e1005103
Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease.
Eur Heart J. 2015 Jun 14;36(23):1454-62
Effects of home telemonitoring interventions on patients with chronic heart failure: an overview of systematic reviews.
J Med Internet Res. 2015;17(3):e63
Examining the clinical use of hemochromatosis genetic testing.
Can J Gastroenterol Hepatol. 2015 Jan-Feb;29(1):41-5
Testosterone suppression in opioid users: a systematic review and meta-analysis.
Drug Alcohol Depend. 2015 Apr 1;149:1-9
Genetic studies of body mass index yield new insights for obesity biology.
Nature. 2015 Feb 12;518(7538):197-206
New genetic loci link adipose and insulin biology to body fat distribution.
Nature. 2015 Feb 12;518(7538):187-96
Adoption, use, and impact of e-booking in private medical practices: mixed-methods evaluation of a two-year showcase project in Canada.
JMIR Med Inform. 2014;2(2):e24
Active metabolite concentration of clopidogrel in patients taking different doses of aspirin: results of the interaction trial.
J Thromb Haemost. 2015 Mar;13(3):347-52
Multiple daily doses of acetyl-salicylic acid (ASA) overcome reduced platelet response to once-daily ASA after coronary artery bypass graft surgery: a pilot randomized controlled trial.
J Thromb Haemost. 2015 Mar;13(3):448-56
Recommendations from the international stroke genetics consortium, part 2: biological sample collection and storage.
Stroke. 2015 Jan;46(1):285-90
Variability of ethics education in laboratory medicine training programs: results of an international survey.
Clin Chim Acta. 2015 Mar 10;442:115-8
Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation.
Neuropsychiatr Dis Treat. 2014;10:2239-47
Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis.
Circ Cardiovasc Genet. 2015 Feb;8(1):82-90
A robust method for iodine status determination in epidemiological studies by capillary electrophoresis.
Anal Chem. 2014 Oct 21;86(20):10010-5
The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol.
Syst Rev. 2014;3:105
A gene variant in CERS2 is associated with rate of increase in albuminuria in patients with diabetes from ONTARGET and TRANSCEND.
PLoS One. 2014;9(9):e106631
The preventive potential of common, easily measured risk factors for cardiovascular disease.
Clin Chem. 2014 Nov;60(11):1450-1
Genetic influence on methadone treatment outcomes in patients undergoing methadone maintenance treatment for opioid addiction: a pilot study.
Neuropsychiatr Dis Treat. 2014;10:1503-8
Methadone induces testosterone suppression in patients with opioid addiction.
Sci Rep. 2014;4:6189
Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?
Diabetologia. 2014 Nov;57(11):2270-81
Urinary sodium and potassium excretion, mortality, and cardiovascular events.
N Engl J Med. 2014 Aug 14;371(7):612-23
Association of urinary sodium and potassium excretion with blood pressure.
N Engl J Med. 2014 Aug 14;371(7):601-11
Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.
Neurology. 2014 Aug 19;83(8):678-85
The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.
Drug Metabol Drug Interact. 2014;29(3):143-51
Barriers to organizational adoption of EMR systems in family physician practices: a mixed-methods study in Canada.
Int J Med Inform. 2014 Aug;83(8):548-58
Research capacity. Enabling the genomic revolution in Africa.
Science. 2014 Jun 20;344(6190):1346-8